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KMID : 0616120090400030205
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 3 p.205 ~ p.212
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In Vivo Toxicity and Anti-Tumor Activity of Korean Mistletoe Extracts
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Yoon Taek-Joon
Park Sung-Min
Yang Seung-Hoon
Jung Hoe-Yune
Lee An-Na
Yoo Young-Choon
Kang Tae-Bong
Kim Jong-Bae
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Abstract
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Antitumor activity of Korean mistletoe extract (KM-110) and European commercial mistletoe preparation (Helixor) was investigated. KM-110 showed the cytotoxic effect that it is high for various tumor cell lines and normal splenocytes in comparison with Helixor. Administration of two mistletoe extracts (100㎍) to mice did not show any significant changes on the level of glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvate transaminase (GTP), blood creatinine (CRE) and blood urea nitrogen (BUN) in sera. The culture supernatant of macrophages stimulated with KM-110 inhibited effectively tumor growth whereas Helixor had little effect. Administration of KM-110 or Helixor resulted in a effective inhibition of lung metastasis after the i.v. inoculation of colon 26-M3.1 lung carcinoma, B16-BL6 melanoma and L5178Y-ML25 lymphomas. In all cases, the mice treated with KM-110 showed more effective anti-tumor metastatic activity than the mice of Helixor. These results suggest that Korean mistletoe extracts, KM-110 might be used as an alternative methods having antitumor activity like European mistletoe preparation, Helixor.
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KEYWORD
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Viscum album, cytotoxicity, macrophage, tumor metastasis
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